Skip to main content
For US Residents Only

Hypoactive sexual desire disorder (HSDD) is defined as ongoing low sexual desire that women find frustrating. Many women haven’t heard of it, but it’s been a recognized medical condition for over four decades.

~one in ten?!

HSDD is common.

In fact, approximately 1 in 10 premenopausal women in the US has it.

How does HSDD happen?

Well, it’s been known for a long time that the brain is responsible for sexual desire. Women who have HSDD have an imbalance of neurotransmitter (chemical messengers) activity in the brain, resulting in low sexual desire.


Vyleesi is for premenopausal women with acquired, generalized HSDD.

“Acquired” means that you were happy with your level of sexual desire in the past, but it has recently decreased.

“Generalized” means that your level of sexual desire is the same, no matter the sexual activity, situation, or sexual partner.

Do not use Vyleesi if you have:

  • high blood pressure that is not controlled (uncontrolled hypertension)
  • known heart (cardiovascular) disease


Here’s what you may be experiencing:


    It could impact how you see yourself. (You don’t have to accept this anymore.)


    It may make you want to stay away from romantic encounters. (If you’re missing that closeness, you deserve better.)


    It can even impact your confidence. (This doesn’t have to be the new normal.)


How do you know if you have HSDD?

Because HSDD is a medical condition, you would need to consult your healthcare professional, either in person or through telemedicine. There is no single lab test to confirm the diagnosis of HSDD.

A validated tool for diagnosing is the Decreased Sexual Desire Screener (DSDS), a short series of questions that focus on the symptoms of HSDD.

HSDD Symptom Checker

Check your symptoms and understand if what you are experiencing might be HSDD before you talk to a healthcare professional.


Don't forget this part.


Do not use VYLEESI if you have:

  • high blood pressure that is not controlled (uncontrolled hypertension)
  • known heart (cardiovascular) disease

Before using VYLEESI, tell your healthcare provider about all of your medical conditions, including if you:

  • have high blood pressure.
  • have heart problems.
  • have kidney problems.
  • have liver problems.
  • are pregnant or plan to become pregnant. It is not known if VYLEESI will harm your unborn baby.
    • Women who can become pregnant should use effective birth control during treatment with Vyleesi.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VYLEESI may affect the way other medicines work, and other medicines may affect the way VYLEESI works.

How should I use VYLEESI?
  • Inject Vyleesi at least 45 minutes before you think that you will begin sexual activity.
  • Do not inject more than 1 dose of VYLEESI within 24 hours of your last dose.
  • Do not inject more than 8 doses of VYLEESI within a month.
What are the possible side effects of VYLEESI?

VYLEESI can cause serious side effects, including:

  • Temporary increase in blood pressure and decrease in heart rate: An increase in blood pressure and decrease in heart rate can happen shortly after you inject VYLEESI. These changes usually go away within 12 hours after your injection. Increases in blood pressure and an increased risk of heart (cardiovascular) problems can happen if you use VYLEESI more often than prescribed by your healthcare provider.
  • Darkening of the skin on certain parts of the body (focal hyperpigmentation) including the face, gums (gingiva) and breast. The chance of darkening of the skin is increased in people with darker skin color. The chance of darkening of the skin is higher if VYLEESI is used every day. Darkening of the skin may not go away, even after you stop using VYLEESI.
  • Nausea. Nausea is common and can also be severe. Nausea most commonly happens after the first VYLEESI injection but can also happen after any dose of VYLEESI. The nausea usually lasts for about 2 hours but can last longer in some people. The nausea usually goes away by itself. Tell your healthcare provider if you have nausea that is severe or does not go away.

The most common side effects of VYLEESI include: flushing, injection site reactions, headache, vomiting, cough, fatigue, hot flush, tingling, dizziness, and nasal congestion. These are not all the possible side effects of VYLEESI.

Call your doctor for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS, contact Palatin Technologies at 1-800-972-5220 or FDA at 1-800-FDA-1088 or

What is VYLEESI?

VYLEESI is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. Women with HSDD have low sexual desire that is troubling to them. Their low sexual desire is not due to:

  • a medical or mental health problem
  • problems in the relationship
  • medicine or other drug use

VYLEESI is not for the treatment of HSDD in women who have gone through menopause or in men.
VYLEESI is not for use to improve sexual performance.
VYLEESI is not for use in children.

Book Virtual Appointment

with an independent healthcare provider

Book Now