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Reconnect with your desire

Vyleesi is the first and only FDA-approved as-needed treatment for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Developed to help women rekindle their sexual desire—on their terms.

The benefits
of Vyleesi

Sexual desire is connected to our self-esteem and the intimacy we have with our partners. If you’re frustrated by low sexual desire, Vyleesi may be for you. Here’s why:

Increases sexual desire

And reduces related distress.

Taken when you choose

You say when the time is right.
For romance, fun, or just because.

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Starts working in ~45 minutes

And keeps working all day or all night for most, 8-10 hours.*

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No alcohol restrictions

Say cheers to your connection.

Vyleesi can cause serious side effects, including temporary increase in blood pressure and decrease in heart rate, darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast, and nausea.

*Do not take Vyleesi more than one time within 24 hours or more than 8 times per month.
Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.

Find out how Vyleesi works

Learn More >

Vyleesi can cause serious side effects, including temporary increase in blood pressure and decrease in heart rate, darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast, and nausea.

*Do not take Vyleesi more than one time within 24 hours or more than 8 times per month.
Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.

Open the door
to desire

Talk to your doctor, or go through telemedicine to get Vyleesi prescribed and delivered from the comfort of your home.
Most eligible patients pay $0 for their prescription!
View complete eligibility terms & conditions
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Answer a few questions

Fill out a quick and private medical questionnaire to see if what you’re experiencing is HSDD.

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Connect online

Our licensed healthcare professionals, experienced in HSDD, will see if Vyleesi is right for you.

Get Vyleesi at your door

If you get a prescription, Vyleesi will ship directly and discreetly, for free.

Need help talking about it?

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Could I have HSDD?

Millions of women experience HSDD, but many haven’t even heard of it. While it’s normal to experience changes in your level of desire, an ongoing struggle to get in the mood can point to an imbalance of chemicals in your brain. The good news is it can be treated. And when it is, women can get back to butterflies, goosebumps, and all the things that come with desire.

Take our short quiz below to find out if what you’re experiencing could be HSDD.

Vyleesi:
the desired results

In a study with real women who struggled with the frustration of low sexual desire, Vyleesi was clinically proven to increase sexual desire and reduce related stress, which impacts overall wellness. In fact, nearly 80% of women who completed the study volunteered for an additional one-year extension. Here are some of their stories.

Vyleesi can cause serious side effects, including temporary increase in blood pressure and decrease in heart rate, darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast, and nausea.

Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.

Vyleesi is affordable

Most commercially insured patients get Vyleesi at no cost.
And if you don’t have prescription drug insurance, don’t worry. We’ll help get Vyleesi at a discounted price. That way, nothing can stand in the way of your desire!

Most commercially insured patients get Vyleesi at no cost. And if you don’t have prescription drug insurance, we’ll help get Vyleesi at a discounted price.
View complete eligibility terms & conditions

What is HSDD?

1 in 10 premenopausal women experience HSDD (Hypoactive Sexual Desire Disorder).

It’s the most common medical condition to cause sex-related distress for women—affecting self-esteem and putting a strain on relationships—but many women don’t discuss it with their doctors, and it often goes undiagnosed. If you’re experiencing an ongoing and frustrating lack of sexual desire, you’re not alone. Understand what causes HSDD and see if FDA-approved Vyleesi is the right treatment option for you.

Are you experiencing HSDD?

Symptom Checker >

Frequently asked questions

That’s the abbreviation for hypoactive sexual desire disorder. It’s a common, treatable medical condition characterized by ongoing low sexual desire that women find frustrating (“hypoactive” means “low”).

If you’re diagnosed with “acquired, generalized” HSDD, it means you haven’t had low sexual desire in the past, but you now have low sexual desire no matter the sexual activity, situation, or sexual partner.

If you’ve never heard of HSDD, you’re not alone. One survey showed that 72% of premenopausal women weren’t aware of HSDD,* even though about 10% of premenopausal women in the US have it.

Think you have symptoms of HSDD? Check it out.

*Kingsberg S.A. Attitudinal survey of women living with low sexual desire. J Women’s Health. 2014;23(10):8

Vyleesi (bremelanotide injection) is the first and only FDA-approved as-needed treatment for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). It was approved by the FDA on June 21, 2019.

Do not use if you have:

  • high blood pressure that is not controlled (uncontrolled hypertension)
  • known heart (cardiovascular) disease

See clinical trials info.

Here’s what two identically designed clinical trials with over 1,200 premenopausal women with HSDD* showed:

Vyleesi increased sexual desire and reduced related distress.

Women who took Vyleesi experienced continued meaningful improvement of HSDD symptoms, with nearly 80% of women who completed the clinical study volunteering for an additional one-year extension.

The most common side effects are nausea, flushing, injection site reactions, headache, and vomiting.


*The effectiveness and safety of Vyleesi were studied in two identical trials in over 1,200 premenopausal women with acquired, generalized HSDD for at least six months. Ages ranged from 19-56 years old, with an average age of 39 years old; 86% were White and 12% were Black. The trials had two phases: a 24-week Core Study Phase (24-week placebo-controlled, double-blind treatment period) and an uncontrolled 52-week Open-label Extension Study Phase in which nearly 700 patients received Vyleesi. Most people who received Vyleesi used it two to three times per month and no more than once a week.

Serious adverse reactions were reported in 1.1% of Vyleesi-treated patients and 0.5% of placebo-treated patients.

Important Safety Information

Do not use Vyleesi if you have:
  • high blood pressure that is not controlled (uncontrolled hypertension)

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with a healthcare provider now.

Important Safety Information

Do not use Vyleesi if you have:
  • high blood pressure that is not controlled (uncontrolled hypertension)
  • known heart (cardiovascular) disease
Before using Vyleesi, tell your healthcare provider about all of your medical conditions, including if you:
  • have high blood pressure.
  • have heart problems.
  • have kidney problems.
  • have liver problems.
  • are pregnant or plan to become pregnant. It is not known if Vyleesi will harm your unborn baby.
    • Women who can become pregnant should use effective birth control during treatment with Vyleesi.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Vyleesi may affect the way other medicines work, and other medicines may affect the way Vyleesi works.

How should I use Vyleesi?
  • Inject Vyleesi at least 45 minutes before you think that you will begin sexual activity.
  • Do not inject more than 1 dose of Vyleesi within 24 hours of your last dose.
  • Do not inject more than 8 doses of Vyleesi within a month.
What are the possible side effects of Vyleesi? Vyleesi can cause serious side effects, including:
  • Temporary increase in blood pressure and decrease in heart rate: An increase in blood pressure and decrease in heart rate can happen shortly after you inject Vyleesi. These changes usually go away within 12 hours after your injection. Increases in blood pressure and an increased risk of heart (cardiovascular) problems can happen if you use Vyleesi more often than prescribed by your healthcare provider.
  • Darkening of the skin on certain parts of the body (focal hyperpigmentation), including the face, gums (gingiva), and breast. The chance of darkening of the skin is increased in people with darker skin color. The chance of darkening of the skin is higher if Vyleesi is used every day. Darkening of the skin may not go away, even after you stop using Vyleesi.
  • Nausea. Nausea is common and can also be severe. Nausea most commonly happens after the first Vyleesi injection but can also happen after any dose of Vyleesi. The nausea usually lasts for about 2 hours but can last longer in some people. The nausea usually goes away by itself. Tell your healthcare provider if you have nausea that is severe or does not go away.

The most common side effects of Vyleesi include: flushing, injection site reactions, headache, vomiting, cough, fatigue, hot flush, tingling, dizziness, and nasal congestion. These are not all the possible side effects of Vyleesi.

Call your doctor for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS, contact Palatin Technologies at 1-800-972-5220 or FDA at 1-800-FDA-1088 or fda.gov/medwatch.

INDICATION What is Vyleesi?

Vyleesi is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. Women with HSDD have low sexual desire that is troubling to them. Their low sexual desire is not due to:

  • a medical or mental health problem
  • problems in the relationship
  • medicine or other drug use

Vyleesi is not for the treatment of HSDD in women who have gone through menopause or in men.

Vyleesi is not for use to improve sexual performance.

Vyleesi is not for use in children.

Terms & Conditions

*Depending on your insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc.) are not eligible.

Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Palatin contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Palatin copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.

Get a diagnosis

If your healthcare provider suspects that you may have HSDD, he or she will likely ask you 5 questions from the Decreased Sexual Desire Screener (DSDS). Here’s what to expect:

  1. In the past, was your level of sexual desire or interest good and satisfying to you?
  2. Has there been a decrease in your level of sexual desire or interest?
  3. Are you bothered by your decreased level of sexual desire or interest?
  4. Would you like your level of sexual desire or interest to increase?
  5. Please check any of the factors that you feel may be contributing to your current decrease in sexual desire or interest:

Quick Question

Are you a healthcare professional in the United States?

This website is intended for US healthcare professionals only.

Getting back your desire with Vyleesi could be just a few clicks away.

Most eligible patients will pay $0 for their Vyleesi prescription!*

Connect online with a licensed physician to see if Vyleesi is right for you

You are now leaving Vyleesi.com to go to our telemedicine partner’s site (Prescribery)

Palatin is not affiliated with healthcare providers, does not make any recommendations of specific healthcare providers, and is not responsible for information you share with them. Any prescription is the decision of the healthcare provider alone, based on the patient’s needs. Palatin does not accept any responsibility for the care, treatment, or advice received from any healthcare provider.

*View complete eligibility terms & conditions

Terms & Conditions

Depending on your insurance coverage, most eligible patients may pay as little as $0. Each patient’s eligibility is evaluated on an individual basis. Patients must be 18 or older to qualify. These programs and any assistance provided may be discontinued or modified at any time based on eligibility, state and local laws, and program availability. Patients insured by a government-funded program (Medicaid, TRICARE, etc.) are not eligible.

Financial assistance applies to the patient’s copay, coinsurance, or deductible for patients receiving Vyleesi. Palatin contributions against patient deductible and/or out-of-pocket maximums are subject to possible health plan restrictions. Palatin copay assistance will only apply to 2 fills every 30 days. Enrollment into the program cannot be retroactive.